The piperine derivative HJ105 inhibits Aβ1–42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis
Xiping Yang, Jingke Zhi, Haifeng Leng, Yu Chen, Haoran Gao, Jinming Ma, Jing Ji, Qinghua Hu
Topics & Concepts
TXNIPNeuroprotectionPiperinePharmacologyMorris water navigation taskChemistryNeuroinflammationDownregulation and upregulationKEAP1In vivoHippocampusWestern blotHippocampal formationOxidative stressMedicineBiochemistryBiologyEndocrinologyInternal medicineInflammationBiotechnologyGeneThioredoxinTranscription factorPiperaceae Chemical and Biological StudiesCholinesterase and Neurodegenerative DiseasesMedicinal Plants and Neuroprotection