Pd(PPh3)4 Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug
Jagan Mohana Rao Saketi, S. N. Murthy Boddapati, Raghuram M., Syed Farooq Adil, Mohammed Rafi Shaik, Osamah Alduhaish, Mohammed Rafiq H. Siddiqui, Hari Babu Bollikolla
Abstract
A series of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields by coupling with several arylboronic acids and methylation by two dissimilar approaches. The as-prepared indazole derivatives (3a–3j) and their N-methyl derivatives (5a–5j) are evaluated for in vitro anticancer activity against two cancer cell lines, HCT-116 and MDA-MB-231. The results reveal that the indazole derivatives tested display mild to moderate anticancer activities against the cell lines tested.
Topics & Concepts
IndazoleChemistryArylCombinatorial chemistryAnticancer drugCancer cell linesIn vitroStereochemistryDrugPharmacologyCancer cellCancerOrganic chemistryBiochemistryBiologyAlkylGeneticsCatalytic C–H Functionalization MethodsClick Chemistry and ApplicationsCatalytic Cross-Coupling Reactions