1,2-Disubstituted bicyclo[2.1.1]hexanes as saturated bioisosteres of <i>ortho</i>-substituted benzene
Aleksandr Denisenko, Pavel Garbuz, Yelyzaveta Makovetska, Oleh Shablykin, Dmytro Lesyk, Galeb Al-Maali, Rodion Korzh, Iryna V. Sadkova, Pavel K. Mykhailiuk
Abstract
-substituted benzene ring. The incorporation of the 1,2-disubstituted bicyclo[2.1.1]hexane core into the structure of fungicides boscalid (BASF), bixafen (Bayer CS), and fluxapyroxad (BASF) gave saturated patent-free analogs with high antifungal activity.
Topics & Concepts
Bicyclic moleculeBenzeneMedicinal chemistryChemistryStereochemistryOrganic chemistryOrganic Chemistry Cycloaddition ReactionsOxidative Organic Chemistry ReactionsRadical Photochemical Reactions