CRTC3, a sensor and key regulator for melanogenesis, as a tunable therapeutic target for pigmentary disorders
Hanju Yoo, Ha-Ri Lee, Ki Hyun Kim, Minah Kim, Seunghyun Bang, Youngho Kang, Woo-Hyung Kim, Youngsup Song, Sung Eun Chang
Abstract
CRTC3 appears to be a key sensor for melanogenesis and can be used as a reversible and tunable tool for selectively regulating melanogenesis without affecting melanocyte integrity. Thus, CRTC3 can also serve as a screening tool for the discovery of ideal melanogenesis-modulating small molecules.
Topics & Concepts
Microphthalmia-associated transcription factorMelaninCREBBiologyHuman skinTransgeneCell biologyMelanocortin 1 receptorNull alleleMelanocyteMolecular biologyTranscription factorPhenotypeCancer researchGeneGeneticsMelanomamelanin and skin pigmentationBiochemical Analysis and Sensing TechniquesOlfactory and Sensory Function Studies