Seleno Containing Compounds as Potent and Selective Antifungal Agents
Andrea Angeli, Alice Velluzzi, Silvia Selleri, Clemente Capasso, Costanza Spadini, Mattia Iannarelli, Clotilde Silvia Cabassi, Fabrizio Carta, Claudiu T. Supuran
Abstract
. Safe cytotoxicity profiles on bovine kidney cells (MDBK) and human HaCat cells, as well as the shallow hemolytic activity on defibrinated sheep blood, allowed us to consider these compounds as up-and-coming novel antifungals.
Topics & Concepts
CytotoxicityHaCaTAntifungalMalasseziaMicrobiologyChemistryToxicityCandida albicansDrugSulfonamideBiologyBiochemistryPharmacologyIn vitroStereochemistryOrganic chemistryEnzyme function and inhibitionCholinesterase and Neurodegenerative DiseasesPhenothiazines and Benzothiazines Synthesis and Activities