Local miRNA-Dependent Translational Control of GABAAR Synthesis during Inhibitory Long-Term Potentiation
Dipen Rajgor, Alicia Purkey, Jennifer L. Sanderson, Theresa M. Welle, Joshua D Garcia, Mark L. Dell’Acqua, Katharine R. Smith
Abstract
Rs occurs exclusively in dendrites and in a miR376c-dependent manner following iLTP. Together, this work describes a local post-transcriptional mechanism that regulates inhibitory synaptic plasticity via miRNA control of dendritic protein synthesis.
Topics & Concepts
Long-term potentiationInhibitory postsynaptic potentialSynaptic plasticityPostsynaptic potentialTranslation (biology)NeuroscienceCell biologyNeurotransmissionBiologyLTP inductionPsychological repressionGABAA receptorChemistryExcitatory postsynaptic potentialMessenger RNAReceptorGene expressionBiochemistryGeneNeuroscience and Neuropharmacology ResearchMicroRNA in disease regulationRNA regulation and disease