Catalytic asymmetric formal (2 + 3) cycloaddition involving methyl-substituted 2-indolylmethanols
Sijia Liu, Tian‐Zhen Li, Ning‐Yi Wang, Qi Cheng, Yinchun Jiao, Yu‐Chen Zhang, Feng Shi
Abstract
A catalytic asymmetric formal (2 + 3) cycloaddition of methyl-substituted 2-indolylmethanols was established, which delivered various chiral pyrroloindoles in overall high yields with excellent diastereoselectivities and good enantioselectivities.
Topics & Concepts
CycloadditionChemistryCatalysisFormal synthesisEnantioselective synthesisCombinatorial chemistryOrganic chemistrySynthesis of Indole DerivativesAsymmetric Synthesis and CatalysisOxidative Organic Chemistry Reactions