Oncogene Convergence in Extrachromosomal DNA Hubs
Natasha E. Weiser, King L. Hung, Howard Y. Chang
Abstract
Extrachromosomal DNA circles (ecDNA) are a common mechanism for oncogene amplification and are associated with worse clinical outcomes compared with other types of oncogene amplification. Several recent discoveries of ecDNA hubs-local congregations of ecDNAs in the nucleus-highlight unique features of ecDNA biology that may contribute to higher oncogene expression and rapid tumor evolution.
Topics & Concepts
Extrachromosomal DNAOncogeneDNABiologyComputational biologyConvergence (economics)GeneticsOncogene ProteinsMechanism (biology)Expression (computer science)RET proto-oncogeneComputer scienceCancer researchHuman geneticsMutationCancerCell biologyCancer Genomics and DiagnosticsMicrotubule and mitosis dynamicsGenomic variations and chromosomal abnormalities