Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection
Elizabeth M. Parzych, Sunita Gulati, Bo Zheng, Mamadou A. Bah, Sarah T. C. Elliott, Jacqueline D. Chu, Nancy Nowak, George Reed, Frank J. Beurskens, Janine Schuurman, Peter A. Rice, David B. Weiner, Sanjay Ram
Abstract
The ensuing rapid and sustained MAb 2C7 expression attenuated gonococcal colonization in mice at 8 days as well as 65 days postadministration. The DMAb system may provide an effective, economical platform to deliver MAbs for durable protection against gonorrhea.
Topics & Concepts
Monoclonal antibodyNeisseria gonorrhoeaeIn vivoComplement systemRecombinant DNABiologyAntibodyEpitopeMicrobiologyImmunologyGeneBiochemistryGeneticsReproductive tract infections researchBacterial Infections and VaccinesBlood groups and transfusion