Carrier gas triggered controlled biolistic delivery of DNA and protein therapeutics from metal–organic frameworks
Yalini H. Wijesundara, Fabian C. Herbert, Orikeda Trashi, Ikeda Trashi, Olivia R. Brohlin, Sneha Kumari, Thomas S. Howlett, Candace Benjamin, Arezoo Shahrivarkevishahi, Shashini D. Diwakara, Sachini D. Perera, Samuel A. Cornelius, Juan P. Vizuet, Kenneth J. Balkus, Ronald A. Smaldone, Nicole J. De Nisco, Jeremiah J. Gassensmith
Abstract
is used, it creates a transient and weakly acidic local environment that causes a near-instantaneous release of the biomolecules through an immediate dissolution of ZIF-8. Conversely, when air is used, ZIF-8 biodegrades slowly, releasing the biomolecules over a week. This is the first example of controlled-biolistic delivery of biomolecules using ZIF-8, which provides a powerful tool for fundamental and applied science research.