<i>Chop</i> / <i>Ddit3</i> depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice
Jing Yong, Vishal S. Parekh, Shannon M. Reilly, Jonamani Nayak, Zhouji Chen, Cynthia Lebeaupin, Insook Jang, Jiangwei Zhang, Thazha P. Prakash, Hong Sun, Sue Murray, Shuling Guo, Julio E. Ayala, Leslie S. Satin, Alan R. Saltiel, Randal J. Kaufman
Abstract
depletion in β cells provides a therapeutic strategy to alleviate dysregulated insulin secretion and consequent fatty liver disease in T2D.
Topics & Concepts
SteatosisCHOPUnfolded protein responseSecretionCancer researchEndocrinologyMedicineFatty liverInternal medicineEndoplasmic reticulumBiologyCell biologyDiseasePancreatic function and diabetesDiabetes and associated disordersDiet, Metabolism, and Disease