Osteoporosis in Inflammatory Arthritides: New Perspective on Pathogenesis and Treatment
Denise Rotta, Angelo Fassio, Maurizio Rossini, Alessandro Giollo, Ombretta Viapiana, Giovanni Orsolini, Eugenia Bertoldo, Davide Gatti, Giovanni Adami
Abstract
Osteoporosis is a skeletal disorder characterized by impaired bone strength and increased risk of fragility fracture and is among the most relevant comorbidities of rheumatic diseases. The purpose of the present review is to discuss the pathogenesis of local and systemic bone involvement in inflammatory arthritides, especially Rheumatoid Arthritis, Psoriatic Arthritis, and Spondyloarthritides, as well as the effect of anti-rheumatic treatments and anti-osteoporotic medication on bone health and fracture incidence, including recent data on novel therapeutic perspective.
Topics & Concepts
MedicineRheumatoid arthritisOsteoporosisPathogenesisPsoriatic arthritisIncidence (geometry)Ankylosing spondylitisSkeletal disorderArthritisInternal medicineOpticsPhysicsRheumatoid Arthritis Research and TherapiesSpondyloarthritis Studies and TreatmentsBone and Joint Diseases