An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function
Maltesh Kambali, Yan Li, Petr Unichenko, Jessica Abigail Feria Pliego, Rachita Yadav, Jing Liu, Patrick S. McGuinness, Johanna G. Cobb, Muxiao Wang, Rajasekar Nagarajan, Jinrui Lyu, Vanessa Vongsouthi, Colin J. Jackson, Elif Engin, Joseph T. Coyle, Jaeweon Shin, Nathaniel Hodgson, Takao K. Hensch, Michael E. Talkowski, Gregg E. Homanics, Vadim Y. Bolshakov, Christian Henneberger, Uwe Rudolph
Topics & Concepts
Dentate gyrusNeuroscienceNMDA receptorPsychosisGlycineLong-term potentiationSchizophrenia (object-oriented programming)ChemistryHippocampal formationBiologyPsychologyBiochemistryReceptorPsychiatryAmino acidNeuroscience and Neuropharmacology ResearchTryptophan and brain disordersNeurotransmitter Receptor Influence on Behavior