Immunomodulation of intracranial melanoma in response to blood-tumor barrier opening with focused ultrasound
Colleen T. Curley, Aaron D. Stevens, Alexander S. Mathew, Katarzyna Stasiak, William J. Garrison, G. Wilson Miller, Natasha Sheybani, Víctor H. Engelhard, Timothy N. J. Bullock, Richard J. Price
Abstract
FUS+MBs-mediated BTB/BBB opening elicits signatures of inflammation; however, the response is mild, transient, and unlikely to elicit a systemic response independent of administration of immune adjuvants.
Topics & Concepts
Blood–brain barrierMicrobubblesMedicineImmunotherapyMelanomaTumor microenvironmentImmune systemFocused ultrasoundCancer researchBrain tumorUltrasoundPathologyCentral nervous systemTumor cellsImmunologyInternal medicineRadiologyUltrasound and Hyperthermia ApplicationsPhotoacoustic and Ultrasonic ImagingNanoplatforms for cancer theranostics