Peroxide-cleavable linkers for antibody–drug conjugates
Nicola Ashman, Jonathan D. Bargh, Stephen J. Walsh, Ryan Greenwood, Arnaud Tiberghien, Jason S. Carroll, David R. Spring
Abstract
Peroxide-cleavable arylboronates are stable linkers for the generation of efficacious antibody–drug conjugates.
Topics & Concepts
ConjugatePeroxideDrugChemistryCombinatorial chemistryAntibodyAntibody-drug conjugatePharmacologyMonoclonal antibodyOrganic chemistryMedicineImmunologyMathematical analysisMathematicsHER2/EGFR in Cancer ResearchMonoclonal and Polyclonal Antibodies ResearchRadiopharmaceutical Chemistry and Applications