Intraperitoneal administration of thermosensitive hydrogel Co-loaded with norcantharidin nanoparticles and oxaliplatin inhibits malignant ascites of hepatocellular carcinoma
Susu Xiao, Yu Wang, Wenqiong Ma, Ping Zhou, Biqiong Wang, Zhouxue Wu, Qian Wen, Kang Xiong, Yanlin Liu, Shaozhi Fu
Abstract
, and significantly inhibited ascites formation, tumor cell proliferation and micro-angiogenesis in a mouse model of advanced HCC with ascites, and prolonged the survival of tumor-bearing mice. Histological examination of the major organs indicated that the hydrogel system is safe. Taken together, the N/O/Hydrogel system is a promising platform for in-situ chemotherapy of malignant ascites.
Topics & Concepts
OxaliplatinAscitesHepatocellular carcinomaCancer researchChemotherapyIntraperitoneal injectionMedicineApoptosisPharmacologyInternal medicineCancerChemistryColorectal cancerBiochemistryBeetle Biology and Toxicology StudiesPhytochemical compounds biological activitiesNatural Compounds in Disease Treatment