Tuning anticancer properties and DNA-binding of Pt(<scp>ii</scp>) complexes <i>via</i> alteration of nitrogen softness/basicity of tridentate ligands
Kamelah S. Alrashdi, Bandar A. Babgi, Ehab M. M. Ali, Abdesslem Jedidi, Abdul‐Hamid Emwas, Bambar Davaasuren, Mariusz Jaremko, Mark G. Humphrey
Abstract
values against HepG2 of 6.99 and 10.15 μM, respectively, compared to 19.73 μM for cisplatin. The cell cycle interference behaviour with HepG2 of selected complexes is similar to that of cisplatin, suggesting apoptotic cell death. The current work highlights the impact of the tridentate ligand on the biological properties of platinum complexes.
Topics & Concepts
ChemistryDNANitrogenCombinatorial chemistryStereochemistryBiophysicsBiochemistryOrganic chemistryBiologyMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsDNA and Nucleic Acid Chemistry