Dual-nickel/photoredox-catalyzed acylation of spiro-dihydroquinazolinones with carboxylic acids <i>via</i> an aromatization-driven deconstructive strategy
Wenchao Gao, Yong Teng, Jie Yang, Wendian Li, Wenguang Li, Ke-Xin Huang, Ting Li
Abstract
Dual-nickel/photoredox-catalyzed aromatization-mediated deconstruction and acylation of spiro-dihydroquinazolinones with carboxylic acids serving as acyl electrophiles is described. A series of synthetical ketone scaffolds with functional group tolerance could be obtained under mild conditions. A radical pathway involving an N-centered radical inducing β-scission to form a C-centered radical is proposed for these transformations.
Topics & Concepts
AromatizationAcylationCatalysisChemistryNickelDual (grammatical number)Combinatorial chemistryOrganic chemistryPhotochemistryArtLiteratureRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques