The m6A reader YTHDC2 promotes the pathophysiology of temporal lobe epilepsy by modulating SLC7A11-dependent glutamate dysregulation in astrocytes
Kai Zhang, Zhiquan Yang, Zhuanyi Yang, Liangchao Du, Yu Zhou, Shiyu Fu, Xiaoyue Wang, Xing Li, Dingyang Liu, Xinghui He
Abstract
This study highlights the therapeutic potential of targeting YTHDC2 and xCT in reactive astrocytes to mitigate epilepsy. The findings provide a novel perspective on the mechanisms of glutamate dysregulation and their implications in seizure pathophysiology, suggesting that modulation of YTHDC2 and xCT could be a promising strategy for treating TLE.
Topics & Concepts
NeurosciencePathophysiologyGlutamate receptorEpilepsyTemporal lobeAstrocyteEpileptogenesisChemistryPathologyBiologyMedicineCentral nervous systemReceptorBiochemistryRNA modifications and cancerPeptidase Inhibition and AnalysisGenetics and Neurodevelopmental Disorders