AI-Enhanced Electrochemical Sensing Systems: A Paradigm Shift for Intelligent Food Safety Monitoring
Yuliang Zhao, Tingting Sun, Huawei Zhang, Wen J. Li, Chao Lian, Yongqiang Jiang, Mingyue Qu, Zhongpeng Zhao, Yuhang Wang, Yang Sun, Huiqi Duan, Yuhao Ren, Peng Liu, Xulong Lang, Shaolong Chen
Abstract
Artificial intelligence (AI) is transforming electrochemical biosensing systems, offering novel solutions for foodborne pathogen detection. This review examines the integration of AI technologies, particularly machine learning and deep learning algorithms, in enhancing sensor design, material optimization, and signal processing for detecting key pathogens such as Escherichia coli, Salmonella, and Staphylococcus aureus. Key advancements include improved sensitivity, multiplexed detection, and adaptability to complex environments. The application of AI to the design of recognition molecules (e.g., enzymes, antibodies, aptamers), as well as to electrochemical parameter tuning and multicomponent signal analysis, is systematically reviewed. Additionally, the convergence of AI with the Internet of Things (IoT) is discussed as a pathway to portable, real-time detection platforms. The review highlights the pivotal role of AI across multiple layers of biosensor development, emphasizing the opportunities and challenges that arise from interdisciplinary integration and the practical deployment of IoT-enabled technologies in electrochemical sensing systems. Despite significant progress, challenges remain in data quality, model generalization, and interpretability. The review concludes by outlining future research directions for building robust, intelligent biosensing systems capable of supporting scalable food safety monitoring.