Rhodium(<scp>iii</scp>)-catalyzed C–H/C–F activation sequence: expedient and divergent synthesis of 2-benzylated indoles and 2,2′-bis(indolyl)methanes
Bing Shu, Shaoyong Chen, Nan-Xiang Deng, Tao Zheng, Hui Xie, Xiaoling Xie, Jia‐Qiang Wu, Hua Cao, Shang‐Shi Zhang
Abstract
A novel method for the construction of fluorinated 2-benzylated indoles and 2,2’-bis(indolyl)methanes was developed <italic>via</italic> Rh(<sc>iii</sc>)-catalyzed C–H/C–F activation of arenes with employing 3,3-difluoro-2-exo-methylidene indolines as cross-coupling partner.
Topics & Concepts
ChemistryRhodiumCatalysisSequence (biology)Medicinal chemistryStereochemistryOrganic chemistryBiochemistryFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions