Design, synthesis, anticancer activity and molecular docking of quinoline-based dihydrazone derivatives
Jiaxing Lu, Hai-Rong Lan, Dai Zeng, Junying Song, Yating Hao, Ai‐Ping Xing, Ao Shen, Juan Yuan
Abstract
partial insertion. Additionally, molecular docking also suggests that CDK2 may be one of the targets for 3b and 3c. In a word, 3b and 3c could be suitable candidates for further investigation as chemotherapeutic agents in cancer treatment.
Topics & Concepts
QuinolineChemistryDocking (animal)ApoptosisCombinatorial chemistryDNADerivative (finance)BiochemistryOrganic chemistryMedicineEconomicsFinancial economicsNursingCancer therapeutics and mechanismsCancer Mechanisms and TherapySynthesis and biological activity