ALKHB5-demethylated lncRNA SNHG15 promotes myeloma tumorigenicity by increasing chromatin accessibility and recruiting H3K36me3 modifier SETD2
Lan Yao, Tingting Li, Yao Teng, Jingjing Guo, Hongyong Zhang, Linghui Xia, Qiuling Wu
Abstract
To our knowledge, this study first demonstrated the prognostic significance and biological function of long noncoding RNA (lncRNA) small nucleolar RNA host gene 15 (SNHG15) in multiple myeloma (MM), and indicated a novel revelation on the effect of N6-methyladenosine (m6A)-regulated lncRNA on MM tumorigenicity. Moreover, the novel chromatin-regulatory mechanism of lncRNA by interacting with epigenetic modifiers including m6A demethylase ALKBH5 and H3K36me3 methyltransferase SETD2 in myeloma progression elucidated intricate mechanism of tumor pathogenesis.
Topics & Concepts
DemethylaseBiologyChromatinLong non-coding RNACancer researchHistoneEpigeneticsMethyltransferaseHistone H3RNAHistone methyltransferaseCell biologyGeneMethylationGeneticsRNA modifications and cancerCancer-related molecular mechanisms researchCancer-related gene regulation