Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin
Yingjie Huang, Yan Peng, Jianchao Sun, Shuangxing Li, Junmin Hong, Jie Zhou, Jianchong Chen, Jiansen Yan, Zhengqi Huang, Xiaofei Wang, Weijian Chen, Wei Ye
Topics & Concepts
InflammasomeWestern blotCell biologyMAPK/ERK pathwayChemistryDownregulation and upregulationNicotinamide phosphoribosyltransferaseNF-κBGene knockdownMelatoninSignal transductionCancer researchBiologyBiochemistryEndocrinologyApoptosisNAD+ kinaseReceptorEnzymeGeneInflammasome and immune disordersSpine and Intervertebral Disc PathologySpondyloarthritis Studies and Treatments