Estetrol prevents Western diet–induced obesity and atheroma independently of hepatic estrogen receptor α
Mélissa Buscato, Morgane Davezac, Rana Zahreddine, Marine Adlanmérini, Raphaël Métivier, Marianne Fillet, Gaël Cobraiville, Cédric Moro, Jean-Michel Foidart, Françoise Lenfant, Pierre Gourdy, Jean‐François Arnal, Coralie Fontaine
Abstract
Estetrol prevents obesity, steatosis, and atherosclerosis in mice fed a Western diet. Hepatic ERα is necessary for the prevention of steatosis, but not of obesity and atherosclerosis.
Topics & Concepts
SteatosisInternal medicineObesityEndocrinologyMedicineEstrogen receptorAtheromaEstrogenBreast cancerCancerEstrogen and related hormone effectsCholesterol and Lipid MetabolismFatty Acid Research and Health