Trends of Sex Differences in Clinical Outcomes After Myocardial Infarction in the United States
Andrija Matetić, Warkaa Shamkhani, Muhammad Rashid, Annabelle Santos Volgman, Harriette G.C. Van Spall, Thais Coutinho, Laxmi S. Mehta, Garima Sharma, Purvi Parwani, Mohamed O. Mohamed, Mamas A. Mamas
Abstract
BACKGROUND: Female patients have been shown to experience worse clinical outcomes after acute myocardial infarction (AMI) compared with male patients. However, it is unclear what trend these differences followed over time. METHODS: test was performed to examine the trend of management and in-hospital outcomes over the study period. RESULTS: < 0.001) and these rates have not narrowed over time (2004 vs 2015: aOR, 1.07 [95% CI, 1.04-1.09] vs 1.11 [95% CI, 1.07-1.15), with similar observations recorded for major adverse cardiovascular and cerebrovascular events. CONCLUSIONS: In this temporal analysis of AMI hospitalizations over 12 years, we showed lower receipt of invasive therapies and higher mortality rates in women, with no change in temporal trends. There needs to be a systematic and consistent effort toward exploring these disparities to identify strategies to mitigate them.