Ruthenium-Catalyzed Cross Dehydrogenative Annulation of <i>N</i>-(7-Azaindole)benzamides with Maleimides: One-Step Access to Highly Functionalized Pyrroloisoquinoline
Bedadyuti Vedvyas Pati, Prateep Singh Sagara, Asit Ghosh, Smruti Ranjan Mohanty, Ponneri C. Ravikumar
Abstract
A ruthenium(II)-catalyzed cross dehydrogenative annulation of N-(7-azaindole)benzamides with maleimides has been demonstrated. Herein, we have explored the use of N-amino-7-azaindole as a new bidentate directing group for dehydrogenative [4 + 2] annulation. This method works efficiently, affording a variety of pharmacologically useful 7-azaindole-based isoquinolones and showing a wide functional group tolerance.
Topics & Concepts
AnnulationRutheniumChemistryCatalysisCombinatorial chemistryFunctional groupMedicinal chemistryOrganic chemistryPolymerCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic Reactions