<i>N</i>-Trifluoromethoxyphthalimide: A Shelf-Stable Reagent for Nucleophilic Trifluoromethoxylation
Wenjuan Yuan, Chao‐Lai Tong, Xiu‐Hua Xu, Feng‐Ling Qing
Abstract
Due to the unique properties of the OCF 3 group, trifluoromethyl ether compounds play an important role in pharmaceuticals and agrochemicals. Recently, considerable attention has been focused on the development of practical and convenient reagents for the direct incorporation of the OCF 3 group into organic compounds. Herein, we reported a new trifluoromethoxylating reagent N -trifluoromethoxyphthalimide (Phth-OCF 3 ). The reagent was a stable solid and released an OCF 3 anion under mild reaction conditions. We demonstrated the application of Phth-OCF 3 for the nucleophilic trifluoromethoxylation of various alkyl electrophiles.
Topics & Concepts
ReagentNucleophileTrifluoromethylChemistryEtherElectrophileAlkylOrganic chemistryCombinatorial chemistryCatalysisFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsSynthesis and Reactions of Organic Compounds