Diabetic ferroptosis plays an important role in triggering on inflammation in diabetic wound
Shuangwen Li, Yuan Li, Ziyu Wu, Zhongming Wu, Zhongming Wu, Zhongming Wu, Hongjuan Fang
Abstract
Ferroptosis-related characteristic changes were found in diabetic wound models. Inhibition of ferroptosis improved inflammatory infiltration of diabetic wounds. PI3K/AKT signal pathway was rescued by restraining of ferroptosis. Mitigation of ferroptosis in diabetic wound promoted the wound healing.
Topics & Concepts
Oxidative stressWound healingInflammationReactive oxygen speciesDiabetes mellitusPI3K/AKT/mTOR pathwayLipid peroxidationProtein kinase BMedicinePharmacologyApoptosisCancer researchImmunologyChemistryCell biologyBiologyInternal medicineEndocrinologyBiochemistryCancer-related molecular mechanisms researchFerroptosis and cancer prognosisInflammatory Biomarkers in Disease Prognosis