Alterações da ECA2 e Fatores de Risco para Gravidade da COVID-19 em Pacientes com Idade Avançada
Caio de Assis Moura Tavares, Thiago Junqueira Avelino‐Silva, Gil Benard, Francisco Akira Malta Cardozo, Juliana Ruiz Fernandes, Adriana C. C. Girardi, Wilson Jacob Filho
Abstract
ACE2, SARS-CoV-2 Infection and Aging Abnormalities induced by aging in metabolic pathways may partly explain the higher rate of COVID-19 morbidity and mortality in elderly patients. These include those belonging to the renin-angiotensin system (RAS), given the crucial role that this system plays both in viral transmissibility and in the pathogenesis of acute lung injury and its most severe form: acute respiratory distress syndrome (ARDS). ACE2 is known to act as a receptor for SARS-CoV-2 1 structural protein S (spike), [...]
Topics & Concepts
MedicineARDSPathogenesisCoronavirus disease 2019 (COVID-19)Acute respiratory distressSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)LungAngiotensin-converting enzyme 2Receptor2019-20 coronavirus outbreakRenin–angiotensin systemInternal medicineImmunologyVirologyBlood pressureOutbreakDiseaseInfectious disease (medical specialty)COVID-19 Clinical Research StudiesLong-Term Effects of COVID-19COVID-19 and Mental Health