A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility
Sven Epple, Aman Modi, Ysobel R. Baker, Ewa Węgrzyn, Diallo Traoré, Przemysław Wanat, Agnes E. S. Tyburn, Arun Shivalingam, Lapatrada Taemaitree, Afaf H. El‐Sagheer, Tom Brown
Abstract
has superior replication kinetics to these analogues and is accurately replicated by polymerases. Derived structure-biocompatibility relationships show that linker length and the orientation of a hydrogen bond acceptor are critical and provide further guidance for the rational design of artificial biocompatible nucleic acid backbones.
Topics & Concepts
ChemistryTriazoleCompatibility (geochemistry)PolymeraseDNACombinatorial chemistryDNA polymeraseStereochemistryBiochemistryOrganic chemistryChemical engineeringEngineeringClick Chemistry and ApplicationsAdvanced biosensing and bioanalysis techniquesBacteriophages and microbial interactions