Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review
Ιoannis Ilias, Manfredi Rizzo, Lina Zabulienė
Abstract
Metformin (MTF) occupies a major and fundamental position in the therapeutic management of type 2 diabetes mellitus (T2DM). Gender differences in some effects and actions of MTF have been reported. Women are usually prescribed lower MTF doses compared to men and report more gastrointestinal side effects. The incidence of cardiovascular events in women on MTF has been found to be lower to that of men on MTF. Despite some promising results with MTF regarding pregnancy rates in women with PCOS, the management of gestational diabetes, cancer prevention or adjunctive cancer treatment and COVID-19, most robust meta-analyses have yet to confirm such beneficial effects.
Topics & Concepts
MedicineMetforminGestational diabetesIncidence (geometry)Diabetes mellitusType 2 diabetesPregnancyInternal medicineObstetricsGynecologyEndocrinologyGestationOpticsGeneticsBiologyPhysicsGestational Diabetes Research and ManagementDiabetes Treatment and ManagementOvarian function and disorders