Effect of obesity on sleep apnea pathogenesis differs in women versus men: multiple mediation analyses in the retrospective SNOOzzzE cohort
Brandon Nokes, Jeremy E. Orr, Stephanie White, Steven Luu, Zihan Chen, Raichel M. Alex, Scott A. Sands, Brian S. Wojeck, Robert L. Owens, Atul Malhotra, Christopher N. Schmickl
Abstract
Our data provide important insights into obesity-related obstructive sleep apnea (OSA) pathogenesis, thereby validating, and extending, prior research findings. This is the largest sample size study to examine the relationships between obesity and gender on OSA pathogenesis. The influence of obesity on sleep apnea severity is mediated by different mechanistic traits (endotypes).
Topics & Concepts
Retrospective cohort studyMediationPathogenesisSleep apneaObesityMedicineCohortCohort studyInternal medicineObstructive sleep apneaEndocrinologyLawPolitical scienceObstructive Sleep Apnea ResearchNeuroscience of respiration and sleepVoice and Speech Disorders