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Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo

Meng Liu, Chao Zhang, Ximing Gong, Tian Zhang, Michelle Mulan Lian, Elaine Guo Yan Chew, Angelysia Cardilla, Keiichiro Suzuki, Huamin Wang, Yuan Yuan, Yan Li, Mihir Yogesh Naik, Yixuan Wang, Bing‐Rui Zhou, Wei Ze Soon, Emi Aizawa, Pin Li, Jian Hui Low, Moses Tandiono, Enrique Montagud‐Marrahí, Daniel Moya‐Rull, Concepción Rodrı́guez Esteban, Yosu Luque, Mingliang Fang, Chiea Chuen Khor, Núria Montserrat, Josep M. Campistol, Juan Carlos Izpisúa Belmonte, Jia Nee Foo, Yun Xia

2024Cell stem cell35 citationsDOI

Topics & Concepts

OrganoidAutophagyCiliumBiologyInduced pluripotent stem cellIn vivoPolycystic kidney diseaseCell biologyATG5Cancer researchKidneyEndocrinologyApoptosisEmbryonic stem cellBiotechnologyBiochemistryGeneGenetic and Kidney Cyst DiseasesRenal and related cancersRenal cell carcinoma treatment
Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo | Litcius