Synthesis of graphene quantum dots and their applications in drug delivery
Changhong Zhao, Xuebin Song, Ya Liu, Yifeng Fu, Lilei Ye, Nan Wang, Fan Wang, Lu Li, Mohsen Mohammadniaei, Ming Zhang, Qiqing Zhang, Johan Liu
Abstract
This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.