Imaging Characteristics of Choroid Plexuses in Presymptomatic Multiple Sclerosis
Vito A. G. Ricigliano, Céline Louapre, Émilie Poirion, Annalisa Colombi, Arya Yazdan Panah, Andrea Lazzarotto, Emanuele Morena, Elodie Martin, Michel Bottlaender, Benedetta Bodini, Danielle Seilhean, Bruno Stankoff
Abstract
BACKGROUND AND OBJECTIVES: Recent imaging studies have suggested a possible involvement of the choroid plexus (CP) in multiple sclerosis (MS). Here, we investigated whether CP changes are already detectable at the earliest stage of MS, preceding symptom onset. METHODS: F-DPA-714-PET uptake at the CP level, a postmortem analysis of CPs in MS vs HCs was performed to characterize the cellular localization of TSPO expression. RESULTS: F-DPA-714 uptake. DISCUSSION: We identified an imaging signature in CPs at the presymptomatic MS stage using MRI; in addition, we found an increased CP inflammation with PET in a single presymptomatic patient. These findings suggest a role of CP imaging as an early biomarker and argue for the involvement of the blood-CSF barrier dysfunction in disease development. TRIAL REGISTRATION INFORMATION: APHP-20210727144630, EudraCT-Number: 2008-004174-40; ClinicalTrials.gov: NCT02305264, NCT01651520, and NCT02319382.