Genetic variables of the glutamatergic system associated with treatment-resistant depression: A review of the literature
E. Rodríguez Sáez, Leire Erkoreka, Teresa Moreno-Calle, Belen Berjano, Ana González‐Pinto, Nieves Basterreche, Aurora Arrúe
Abstract
, which encodes the NR2B subunit of NMDAR, as a candidate gene in the pathogenesis of TRD. In addition, several studies have associated genes encoding AMPAR subunits with symptomatic severity and suicidal ideation. These genes encoding glutamatergic receptors could, therefore, be candidate genes for understanding the etiopathogenesis of TRD, as well as for understanding the pharmacodynamic mechanisms and response to ketamine and esketamine treatment.
Topics & Concepts
GlutamatergicAMPA receptorMedicineTreatment-resistant depressionNMDA receptorDepression (economics)NeuroscienceBioinformaticsGlutamate receptorPsychiatryBiologyAntidepressantReceptorInternal medicineAnxietyEconomicsMacroeconomicsTreatment of Major DepressionTryptophan and brain disordersNeuroscience and Neuropharmacology Research