Clostridioides difficile is a bacterial priority pathogen
Wiep Klaas Smits, Kevin W. Garey, Thomas V. Riley, Stuart Johnson
Abstract
Figure illustrating that considering mortality, burden, treatment failure, epidemiology, antimicrobial resistance and current/future treatment modalities [icons from left to right], C. difficile [depicted as a red petritrichous flaggelated bacterium] should be considered a priority pathogen [needle pointing to the red area]. • Clostridioides difficile infections are associated with significant mortality and economic burden. • New epidemic types of C. difficile are emerging. • Community-acquired CDI is increasing and poorly understood. • Reduced susceptibility to antimicrobials, associated with treatment failure, is increasing. • There is paucity of new antimicrobials in clinical development for treatment of CDI.