Unique green chromatographic method for the qualitative and quantitative analysis of ketoconazole, its impurities and preservatives from ketoconazole cream formulation: Identification of degradants by Q-ToF LCMS and Robustness by Design of Experiments
Siva Krishna Muchakayala, Naresh Kumar Katari, Kalyan Kumar Saripella, Vishnu Murthy Marisetti, Leela Prasad Kowtharapu
Topics & Concepts
KetoconazolePreservativeChromatographyChemistryForced degradationHigh-performance liquid chromatographyImpurityReversed-phase chromatographyAntifungalOrganic chemistryMedicineDermatologyAnalytical Methods in PharmaceuticalsAnalytical Chemistry and ChromatographyComputational Drug Discovery Methods