Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing
Shrusti S. Patel, Ella N. Hoogenboezem, Fang Yu, Carlisle R. DeJulius, R. Brock Fletcher, Alexander G. Sorets, Fiona K. Cherry, Justin H. Lo, Mariah G. Bezold, Nora Francini, Richard d’Arcy, Jordan E. Brasuell, Rebecca S. Cook, Craig L. Duvall
Topics & Concepts
Ternary operationGene silencingMaterials sciencePolymerMethacrylateCytotoxicityIn vivoNanocarriersNanoparticleNanotechnologyIn vitroChemistryMonomerBiochemistryBiologyGeneComposite materialComputer scienceBiotechnologyProgramming languageAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery