Identification of the Shigella flexneri Wzy Domain Modulating Wzz <sub>pHS-2</sub> Interaction and Detection of the Wzy/Wzz/Oag Complex
Alice Ascari, Elizabeth Ngoc Hoa Tran, Bart A. Eijkelkamp, Renato Morona
Abstract
Shigella flexneri is a pathogen causing significant morbidity and mortality, predominantly devastating the pediatric age group in developing countries. A major virulence factor contributing to S. flexneri pathogenesis is its surface lipopolysaccharide, which is comprised of three domains: lipid A, core oligosaccharide, and O antigen (Oag).
Topics & Concepts
Shigella flexneriBiologyGeneBinding siteGeneticsBiochemistryEscherichia coliEscherichia coli research studiesBacterial Genetics and BiotechnologyRNA and protein synthesis mechanisms