Synthesis of oxetane and azetidine ethers as ester isosteres by Brønsted acid catalysed alkylation of alcohols with 3-aryl-oxetanols and 3-aryl-azetidinols
Peerawat Saejong, Juan J. Rojas, Camille Denis, Andrew J. P. White, Anne Sophie Voisin‐Chiret, Chulho Choi, James A. Bull
Abstract
3-Aryloxetan-3-ols and 3-arylazetidin-3-ols can be selectively activated to form carbocations and allow reaction with alcohols to form ethers with the 4-membered heterocycles.
Topics & Concepts
OxetaneArylAlkylationChemistryAzetidineOrganic chemistryCarbocationPhthalimidesCatalysisBrønsted–Lowry acid–base theoryMedicinal chemistryPhthalimideAlkylSynthesis and Catalytic ReactionsSynthesis of β-Lactam CompoundsAsymmetric Hydrogenation and Catalysis