Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/β-catenin signal pathway
Liansheng Sha -, Deying Ma, Chen Cuili
Abstract
, silencing Hic-5 remitted the tumor progression. Further, we isolated the exosomes from MG-63 supernatant, exosomes concluding Hic-5 would regulated the proliferation and apoptosis level of MG-63 and HOS cells. Further, Hic-5 interacted with smad4 and regulated Wnt/β-catenin signal by decreasing TCF/LEF activity. Silencing Hic-5 inhibited the proliferation and induced apoptosis of osteosarcoma cell via inactivating Wnt/β-catenin signal by exosome pathway.
Topics & Concepts
Wnt signaling pathwayCateninApoptosisExosomeOsteosarcomaCell biologySignal transductionCancer researchBeta-cateninChemistryMicrovesiclesBiologymicroRNAGeneBiochemistryExtracellular vesicles in diseaseRNA Research and SplicingCircular RNAs in diseases