ISRIB plus bortezomib triggers paraptosis in breast cancer cells via enhanced translation and subsequent proteotoxic stress
Dong Min Lee, Min Ji Seo, Hong Jae Lee, Hyo Joon Jin, Kyeong Sook Choi
Topics & Concepts
BortezomibUnfolded protein responseEndoplasmic reticulumCancer researchApoptosisProteasomeCancer cellBreast cancerCancerProteasome inhibitorMitochondrionProgrammed cell deathChemistryCell biologyBiologyMultiple myelomaMedicineInternal medicineBiochemistryUbiquitin and proteasome pathwaysEndoplasmic Reticulum Stress and DiseaseAutophagy in Disease and Therapy