The use of vitamin E in ocular health: Bridging omics approaches with Tocopherol and Tocotrienol in the management of glaucoma
Fazira Latib, Muhamad Arif Irfan Zafendi, Mohd Aizuddin Mohd Lazaldin
Abstract
• In this review, the transformation of waste Tocopherol and Tocotrienol into valuable resources for pharmaceutical and nutraceutical applications has been highlighted. • Tocopherol and Tocotrienol, derivatives of vitamin E, demonstrate antioxidant and neuroprotective properties that could reduce intraocular pressure and protect optic nerve cells. • Utilizing omics technology enhances the understanding of vitamin E derivatives’ antioxidative mechanisms, aiding in the development of targeted glaucoma therapies. Vitamin E, encompassing tocopherols and tocotrienols is celebrated for its powerful antioxidant properties, which help neutralize free radicals and protect cells from oxidative damage. Over the years, research has shown that both tocopherols and tocotrienols offer significant benefits, including protection against radiation damage, cholesterol regulation, cardiovascular health, and neurological disorders. This wide range of benefits highlights the need for further exploration of vitamin E’s role in managing various diseases. One particularly promising area is its potential application in treating ocular diseases like glaucoma. Despite advances in treatment, current options have limitations, making the investigation of alternative approaches crucial. Omics technologies, which allow for a detailed examination of biological systems, could provide valuable insights into how tocopherols and tocotrienols work at a molecular level. Their neuroprotective and antioxidative properties make them promising candidates for glaucoma management. Additionally, the sustainability of vitamin E is noteworthy, as by-products from its production can be repurposed into valuable resources for nutraceuticals and pharmaceuticals. As research continues, integrating omics technologies with the study of vitamin E derivatives could unveil new therapeutic possibilities, further enhancing our understanding of its diverse health benefits and its potential role in preventing and managing diseases.