Tf<sub>2</sub>O‐Catalyzed Tandem Cyclization/Trifluoromethylselenolation of Alkynes for Synthesis of CF<sub>3</sub>Se‐Containing Heterocycles
Shangbiao Zhang, Yan Gao, Rui Xiao, Yang Li, Yanan Wang, Zheliang Yuan
Abstract
Abstract Herein, the tandem synthesis of various CF 3 Se‐containing heterocyclic compounds has been developed, using Tf 2 O as the catalyst and trifluoromethyl selenoxides as the electrophilic trifluoromethylselenolation reagents. This process is characterized by its mild conditions, ease of operation, and good functional group compatibility. A variety of alkynes could be transferred into CF 3 Se‐containing indoles, benzofurans, benzothiophenes, isoquinolines and chromenes in good yields. A key step involving the formation of the electrophilic CF 3 Se species was proposed.
Topics & Concepts
TandemChemistryElectrophileCatalysisReagentCombinatorial chemistryTrifluoromethylOrganic chemistryMedicinal chemistryMaterials scienceAlkylComposite materialFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesInorganic Fluorides and Related Compounds