A mechanistic study on the regioselective Ni-catalyzed methylation–alkenylation of alkyne with AlMe<sub>3</sub> and allylic alcohol
Jiao Liu, Deguang Liu, Wan Nie, Haizhu Yu, Jing Shi
Abstract
The recently reported Ni-catalyzed methylation–allylation of alkynes with allylic alcohols and AlMe 3 reagents delivers valuable tetrasubstituted alkene units in a highly regioselective fashion.
Topics & Concepts
RegioselectivityChemistryAllylic rearrangementAlkyneAlkeneAlcoholReagentCatalysisMethylationAllylic alcoholCombinatorial chemistryMedicinal chemistryOrganic chemistryBiochemistryGeneCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCatalytic Alkyne Reactions