Effects of morphology and size of nanoscale drug carriers on cellular uptake and internalization process: a review
Wenjie Zhang, Reza Taheri‐Ledari, Fatemeh Ganjali, Seyedeh Shadi Mirmohammadi, Fateme Sadat Qazi, Mahdi Saeidirad, Amir Kashtiaray, Simindokht Zarei-Shokat, Ye Tian, Ali Maleki
Abstract
= 90° is beneficial. Moreover, these nanocarriers show different behaviors when confronting diverse cells whose fields should be investigated in future studies. In this survey, a comprehensive classification based on carrier shape is first submitted. Then, the most commonly used methods for control over the size and shape of the carriers are reviewed. Finally, influential factors on the cellular uptake and internalization processes and related analytical methods for evaluating this process are discussed.
Topics & Concepts
NanocarriersNanorodNanotechnologyMaterials scienceInternalizationDrug deliveryNanoscopic scalePenetration (warfare)Morphology (biology)BiophysicsChemistryCellMathematicsOperations researchBiochemistryGeneticsBiologyRNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryAdvanced biosensing and bioanalysis techniques