Exploration of biomimetic poly(γ-benzyl-<scp>l</scp>-glutamate) fibrous scaffolds for corneal nerve regeneration
Tien-Li Ma, Shang-Chih Yang, Ting Cheng, Mei-Yun Chen, Jo‐Hsuan Wu, Shu‐Lang Liao, Wei‐Li Chen, Wei‐Fang Su
Abstract
confocal microscopy (IVCM) show a low immune response. The corneal neural markers (βIII tubulin and SMI312) in the IHC analysis are consistent with the position stained by glutamate of implanted scaffolds, indicating that PBG induces neurogenesis. PBG exhibits mechanical stiffness to resist material deformation possibly caused by surgical operations. The results of this study demonstrate that PBG is suitable for corneal nerve regeneration and the treatment of neurotrophic keratopathy.
Topics & Concepts
Regeneration (biology)ScaffoldGlutamate receptorMaterials scienceNeurotrophinCell biologyChemistryBiomedical engineeringBiochemistryBiologyMedicineReceptorOcular Surface and Contact LensCorneal Surgery and TreatmentsSilk-based biomaterials and applications