Rhodium‐Catalyzed Synthesis of Isoquinolino[1,2‐<i>b</i>]Quinazolines <i>via</i> C−H Annulation in Biomass‐Derived <i>γ</i>‐Valerolactone
Liang Wang, Kuan‐chang Jiang, Nana Zhang, Zhi‐Hui Zhang
Abstract
Abstract A rhodium‐catalyzed synthesis of isoquinolino[1,2‐ b ]quinazolines via C−H annulation using vinylene carbonate as an oxidizing acetylene surrogate in biomass‐derived γ ‐valerolactone (GVL) has been developed. The reactions proceeded smoothly to give the corresponding products in moderate to good yields without any external oxidant and base. This protocol can also be applied for the synthesis of 5,6‐dihydro‐8 H ‐isoquinolino[1,2‐ b ]quinazolin‐8‐ones.
Topics & Concepts
AnnulationChemistryRhodiumCatalysisOxidizing agentAcetyleneMedicinal chemistryCombinatorial chemistryOrganic chemistryStereochemistryQuinazolinone synthesis and applicationsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis